In 1986 Guillaume graduated in Marketing from the l’Institut Commercial de Nancy (ICN). A pionneer in 3D, he explored digital technologies and created the department of digital special effects of a Paris-based post-production company in 1990. He was then production director at Medialab (a CANAL+ subsidiary).

In 1984 he created the animation and digital SFX studio Sparx* which 10 years later became one of the most important and awarded studio in Europe.

In 2004 Guillaume left Sparx* and in 2005 he created TeamTO with 4 other partners.